Mechanism of Action

CYTALUX™ is a proprietary folic acid analog conjugated with a fluorescent dye which binds to folate receptor positive ovarian cancer cells.

Watch an Animation Describing the
CYTALUX Mechanism of Action

CYTALUX molecule

Folate

Folate is an essential vitamin required for cell growth and DNA replication1

Rapidly dividing cancer cells requires an abundant supply of folate, therefore, it is consumed in elevated quantities1

Most ovarian cancers overexpress high-affinity folate receptors to increase folate uptake for tumor growth2

How CYTALUX Works

CYTALUX is a small
molecule that
circulates quickly
through the body
It can be infused
intravenously in as little as
an hour before imaging.
CYTALUX binds to the
folate receptors on
ovarian cancer cells
It is targeted, preferentially
binding to FR+ ovarian
cancer cells.
CYTALUX is
endocytosed
and concentrates in
folate receptor
positive (FR+) ovarian
cancer tissues
Endocytosis allows it to be
concentrated in the tissues
throughout the entire
surgical procedure.
CYTALUX contains a
bright fluorophore which is
illuminated via near-infrared light
Imaging under near-infrared
light enhances intraoperative
visualization in challenging
environments and below the tissue surface.3

Speak with a representative about CYTALUX and how to bring this technology to your OR.

1 Markert S, et al. Alpha-folate receptor expression in epithelial ovarian carcinoma and nonneoplastic ovarian tissue. Anticancer Res. 2008 (28): 3568-3572.
2 Kalli KR, Oberg AL, Keeney GL, et al. Folate receptor alpha as a tumor target in epithelial ovarian cancer. Gynecologic Oncology. 2008;108(3):619-626.
3 Predina JD, Newton AD, Connolly C, Dunbar A, Baldassari M, Deshpande C, Cantu E 3rd, Stadanlick J, Kularatne SA, Low PS, Singhal S. Identification of a Folate Receptor-Targeted Near-Infrared Molecular Contrast Agent to Localize Pulmonary Adenocarcinomas. Mol Ther. 2018 Feb 7;26(2):390-403. doi: 10.1016/j.ymthe.2017.10.016. Epub 2017 Oct 26. PMID: 29241970; PMCID: PMC5835020.