Mechanism of Action
CYTALUX® is a proprietary folic acid analog conjugated with a fluorescent dye which binds to folate receptor positive cells.
Certain cancers overexpress high-affinity folate receptors to increase folate uptake for tumor growth.1,2
WATCH THE CYTALUX MECHANISM OF
ACTION AT WORK
Folate is an essential vitamin required for cell growth and DNA replication.3
Rapidly dividing cancer cells requires an abundant supply of folate, therefore, it is consumed in elevated quantities.3
How CYTALUX Works
through the body.
intravenously in as little as
an hour before imaging.
folate receptors expressed
binding to FR+ cells.
concentrates in folate
receptor positive (FR+)
ovarian and lung cancer
concentrated in the tissues
throughout the entire
bright fluorophore which
is illuminated via
enhances intraoperative visualization
in challenging environments and
below the tissue surface.1
1 Predina JD, Newton AD, Connolly C, Dunbar A, Baldassari M, Deshpande C, Cantu E 3rd, Stadanlick J, Kularatne SA, Low PS, Singhal S. Identification of a Folate Receptor-Targeted Near-Infrared Molecular Contrast Agent to Localize Pulmonary Adenocarcinomas. Mol Ther. 2018 Feb 7;26(2):390-403. doi: 10.1016/j.ymthe.2017.10.016. Epub 2017 Oct 26. PMID: 29241970; PMCID: PMC5835020.
2 Kalli KR, Oberg AL, Keeney GL, et al. Folate receptor alpha as a tumor target in epithelial ovarian cancer. Gynecologic Oncology. 2008;108(3):619-626.
3 Markert S, et al. Alpha-folate receptor expression in epithelial ovarian carcinoma and nonneoplastic ovarian tissue. Anticancer Res. 2008 (28): 3568-3572.
Speak with a representative
about CYTALUX and how to bring this technology to your OR.